apcgene

由 R Fodde 著作 · 2002 · 被引用 578 次 — Mutations in the adenomatous polyposis coli (APC) gene are not only responsible for familial adenomatous polyposis (FAP), but also play a rate-limiting role ...

The APC gene encodes a multidomain protein that plays a major role in tumor suppression by antagonizing the WNT (see WNT1; 164820) signaling pathway.

由 W Hankey 著作 · 2018 · 被引用 158 次 — The APC gene encodes a 312-kDa protein (Fig. 2) that performs diverse cellular functions and localizes to multiple subcellular compartments. Mutations in APC ...

Most APC mutations cause a condition called Familial Adenomatous Polyposis (FAP). FAP increases your risk for certain types of cancers, including colorectal ( ...

APC gene mutations are found in about 10 to 15 percent of non-inherited (sporadic) desmoid tumors; these mutations are somatic, which means they are acquired ...

2007年10月1日 — The adenomatous polyposis coli (APC) gene is a key tumor suppressor gene. Mutations in the gene have been found not only in most colon ...

2013年3月1日 — The APC gene provides instructions for making the APC protein, which plays a critical role in several cellular processes.

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell ...

APC is classified as a tumor suppressor gene. Tumor suppressor genes prevent the uncontrolled growth of cells that may result in cancerous tumors. The protein ...